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KMID : 1134120100130030250
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Journal of Breast Cancer
2010 Volume.13 No. 3 p.250 ~ p.256
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Lymphovascular Invasion and HER2/neu Amplification as Predictive Factors for Axillary Lymph Node Metastasis in Early Breast Cancer Patients
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Gwak Geum-Hee
Park Kyeong-Mee
Shin Eun-Ah
Han Se-Hwan
Kim Ji-Young
Kim Hong-Yong
Kim Young-Duck
Kim Hong-Joo
Kim Ki-Whan
Bae Byung-Noe
Yang Keun-Ho
Park Sung-Jin
Lim Seung-Woo
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Abstract
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Purpose Axillary lymph node metastasis (ALNM) can occur even in breast cancer smaller than 2 cm in size. This study was performed to investigate the clinicopathologic factors that affect node metastasis in T1 breast cancer.
Methods We reviewed the medical record of 206 T1 breast cancer patients and we divided them into two groups according to the presence or absence of lymph node metastasis. We analyzed the association between ALNM and various clinicopathological predictive factors such as age, tumor size (T1a, T1b, T1c), multiplicity, the histologic grade, the nuclear grade, the presence of lymphovascular invasion (LVI), the estrogen and progesterone receptor status, an HER2/neu expression, the Ki-67 labeling index and the bcl-2 expression.
Results One hundred and thirty-nine were the node negative group (T1N0) and the remaining 67 cases were allotted to the node positive group (T1N1-3). On the univariate analysis, age (p=0.011), LVI (p<0.001), histologic grade (p=0.019), HER2/neu (p<0.005), Ki-67 (p=0.012) and bcl-2 (p=0.026) were the statistically significant predictive factors related to node metastasis. But on the multivariate analysis, LVI (p<0.001) and HER2/neu (p=0.009) were the statistically significant factors related to node metastasis.
Conclusion LVI and HER2/neu overexpression were related to the increased incidence of ALNM in T1 breast cancer patients. LVI was the most predictive factor of ALNM.
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KEYWORD
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Breast neoplasms, HER2/neu, Lymphovascular invasion
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